Yes, the Honda CBR motorcycles, including the CBR250R and other models in the CBR lineup, are generally known for their reliability. Honda has a reputation for producing motorcycles that are dependable and durable, and the CBR series is no exception. The bikes are built with quality components and undergo rigorous testing to ensure their reliability and longevity. However, it's important to note that proper maintenance and regular servicing are crucial in keeping any motorcycle, including the CBR, in optimal condition and maximizing its reliability.